In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeysArticle Published on 2023-02-012023-07-10 Journal: European Journal of Nuclear Medicine and Molecular [Category] COVID19(2023년), [키워드] 89Zr-PET biodistribution monoclonal antibody Physiologically based pharmacokinetics (PBPK) Radiomics respiratory tract SARS-CoV-2 Sotrovimab. [DOI] 10.1007/s00259-022-06012-3 PMC 바로가기
Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Using a “systems therapeutic for physiological renormalization” approach to vaccine development. Covid-19 as an example백신 개발에 "생리학적 재정규화를 위한 시스템 치료" 접근 방식을 사용합니다. 코로나19를 예로 들어Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] 변종, [키워드] adaptive immune system approach current example induce infectious agent mimicry Mutation physiological Prevent Recombination replicate respiratory tract respiratory tracts sera Spread the disease therapeutic Vaccine Vaccine development variant virions virulent [DOI] 10.1080/21645515.2022.2043105 PMC 바로가기 [Article Type] Article
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
Rhinovirus persistence during the COVID-19 pandemic-Impact on pediatric acute wheezing presentationsArticle Published on 2022-11-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] Epidemiology horizontal transmission human rhinovirus 1A Infection Pandemics Pathogenesis respiratory tract virus classification. [DOI] 10.1002/jmv.27986 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccinationArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response B.1.617.2 BAL Blood booster vaccination Breakthrough infection Bronchoalveolar lavage fluid cellular immunity circulating Combination convalescent COVID-19 COVID-19 vaccine D614G Delta demonstrated effective elicit hospitalized patients humoral immune response Immunity immunization individual induce Infection mRNA vaccination mucosal neutralizing antibody Neutralizing antibody response neutralizing antibody responses offer omicron Reinfection respiratory respiratory tract response robust SARS-CoV-2 severe disease significantly lower Support T cell T cell response the SARS-CoV-2 vaccinated individuals variant variants of concern virus VOCs with COVID-19 [DOI] 10.1126/sciimmunol.add4853 PMC 바로가기
Multiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Adults age age and sex association Bacterial caused Characteristics children circulating coronavirus coronavirus disease country COVID-19 COVID-19 pandemic detect detection determine diagnostic Emergency emergency department etiological agent Europe Evidence hospital human coronavirus Human rhinovirus Infection Intervention logistic regression model métapneumovirus Middle East multicenter study Multiplex PCR multiplex PCR assay Nasopharyngeal swab pandemic Panel pathogen Patient PCR prevalent respiratory respiratory pathogen respiratory syncytial virus respiratory tract respiratory tract infection respiratory viruses SARS-CoV-2 significantly higher Stratification Symptom symptomatic Symptoms target targets tested tract utility variety viral infection Viral infection. viruses [DOI] 10.1128/spectrum.02368-22 PMC 바로가기
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant Variant. variants virulence virus virus virus infection virus load WA1 while [DOI] 10.1128/mbio.02421-22 PMC 바로가기
Environmental Impacts on COVID-19: Mechanisms of Increased SusceptibilityArticle Published on 2022-10-212022-11-16 Journal: Annals of Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition age Air pollution antioxidant benefit boost caused changes in children clinical symptom combating coronavirus COVID COVID 19 COVID-19 COVID-19 susceptibility death described disease Diseases Environment Epidemiology exposure to free radical Health host immunity host susceptibility Impact Increased induce Inflammatory cytokine storm inhibit Initially International involved knowledge less mechanism morbidity and mortality outcomes oxidative stress pediatric Preliminary data reduce respiratory tract respiratory viral infections respiratory viral infections. SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severity severity of COVID-19 shown susceptibility susceptible the disease Vaccine variant viral genome viral infections viral pathogenicity while [DOI] 10.5334/aogh.3907 PMC 바로가기